Ongoing Investigations

ADNI data is made available to researchers around the world. As such, there are many active research projects accessing and applying the shared ADNI data. To further encourage Alzheimer’s disease research collaboration, and to help prevent duplicate efforts, the list below shows the specific research focus of the active ADNI investigations. This information is requested annually as a requirement for data access.

Principal Investigator  
Principal Investigator's Name: BHUVANESHWARI BASKARAN
Institution: SSN COLLEGE OF ENGINEERING
Department: MEDICAL ELECTRONICS
Country:
Proposed Analysis: DETECTION OF EARLY ONSET OF ALZHEIMER DISEASE USING fMRI.
Additional Investigators  
Investigator's Name: Guhan N P
Proposed Analysis: Abstract—Alzheimer Disease (AD) is a progressive brain disorder that slowly eradicates memory, behavior and thinking capability. AD is the most collective cause of dementia among adults and progresses from mildest to severe stage where patient completely depends on other for day to day activities. The beta-amyloid plaques and tangles in the brain are considered as the main causes of AD. It features through the loss of brain connectivity between inter and intrahemispherical regions of brain through the progressive stages of AD. In this work the whole brain connectivity patterns for three progressive stages of AD in Posterior Cingulate Cortex (PCC) and Medial Prefrontal Cortex (MPFC) related cortical areas are analyzed from resting state fMRI data. Functional connectivity between the interhemispherical cortical regions has also been estimated through progressive stages of AD using Fisher Z maps. This study concludes that the functional connectivity is decreased in the regions of PCC and MPFC related cortical areas as the disease progress in AD patients.