ADNI data is made available to researchers around the world. As such, there are many active research projects accessing and applying the shared ADNI data. To further encourage Alzheimer’s disease research collaboration, and to help prevent duplicate efforts, the list below shows the specific research focus of the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Ying Zhou |
| Institution: | Xiamen University |
| Department: | Medical School |
| Country: | |
| Proposed Analysis: | In the previous studies, we have found the important functions of SNX27 in Down's syndrome (Wang et al. Nature Medicine, 2013) and Alzheimer's Disease ( Wang et al. Cell Reports, 2014). However, we are not clear weather there are mutations or SNPs in SNX27 linked to an increased AD risk. Thus, we would like to perform human genetic association studies to identify SNPs and mutations located in SNX27 gene linked to an increased AD risk. |
| Additional Investigators | |
| Investigator's Name: | Xin Wang |
| Proposed Analysis: | We will use R package “paramlink” to perform linkage analysis. We will use an extension of the family-based association analysis test (FBAT) approach implemented in PBAT.The FBAT approach evaluates whether the minor allele is over- or undertransmitted (i.e., risk or protection) in affected offspring compared with the expected distribution under Mendel’s law of segregation. FBAT identifies association as well as linkage and minimizes false positive associations due to population stratification. |
