Ongoing Investigations

ADNI data is made available to researchers around the world. As such, there are many active research projects accessing and applying the shared ADNI data. To further encourage Alzheimer’s disease research collaboration, and to help prevent duplicate efforts, the list below shows the specific research focus of the active ADNI investigations. This information is requested annually as a requirement for data access.

Principal Investigator  
Principal Investigator's Name: Murat Ayhan
Institution: Isik University
Department: Department of Computer Engineering
Proposed Analysis: Alzheimer’s disease (AD) is a major cause of dementia. Its diagnosis requires accurate biomarkers that are sensitive to disease stages. Neuroimaging techniques have been used as imaging biomarkers to this end. However, it is virtually impossible to detect visually a slight decrease in regional cerebral blood flow or glucose metabolism in cases of early AD. Also, such an inspection is susceptible to other factors like subjectivity and experience of the physician. On the other hand, voxel-based representations of neuroimagery can be used to perform both standardization and data-driven analysis of brain imagery. In my research, I will regard the induction of a classifier as the creation of a computational biomarker for disease staging and investigate the potential of various predictive modeling techniques, adopting ideas for efficient Bayesian classification, unsupervised feature learning, and model ensembles. As a result of my efforts, I expect to deliver efficient and accurate biomarkers that will speed up the diagnostic processes with no compromise of accuracy and support decision-making based on probabilistic reasoning in cases where there is a lack of access to an experienced physician.
Additional Investigators