There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Greg Carter |
| Institution: | The Jackson Laboratory |
| Department: | Mammalian Genetics |
| Country: | |
| Proposed Analysis: | As part of the IU/JAX Alzheimer's Disease Precision Models Center, funded by NIA to create new animal models of late-onset Alzheimer's Disease (AD), we will use ADNI data to prioritize polygenic candidate models for animal modeling. We will perform genetic association analysis across multiple ADNI phenotypes using novel polygenic association methods. The goal of this analysis will be the identification of specific variants for introduction into rodent models. After the creation of new genetic models, we will perform detailed comparisons of mouse model phenotypes with ADNI data, including imaging modalities pioneered by ADNI. These comparisons will determine the AD pathology captured by each animal model and inform the creation of additional models of late-onset AD. |
| Additional Investigators | |
| Investigator's Name: | Yi Li |
| Proposed Analysis: | Dr Li will carry out polygenic association analysis of quantitative ADNI phenotypes, as part of the IU/JAX MODEL-AD Center. |
| Investigator's Name: | Ravi Pandey |
| Proposed Analysis: | Analyzing WGS data via ADSP. |
| Investigator's Name: | Stephen Keegan |
| Proposed Analysis: | Mr. Keegan will assist Dr. Yi in her analysis. |
| Investigator's Name: | Annat Haber |
| Proposed Analysis: | Dr. Haber will manage secure data for the project. |
| Investigator's Name: | Catrina Spruce |
| Proposed Analysis: | Will work with the MODEL-AD team in managing comparisons between human and mouse imaging and molecular data. |
