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Principal Investigator  
Principal Investigator's Name: Chris Foster
Institution: UT Dallas | Center for Vital Longevity
Department: Brain and Behavioral Sciences
Country:
Proposed Analysis: A large body of literature has linked vascular factors to Alzheimer’s disease (AD), although the nature of that relationship is unclear. Multiple epidemiological studies have shown that specific risk factors for vascular disease such as diabetes and hypertension are also significant risk factors for the cognitive decline that is observed with both normal aging and dementia. Hypertension may be a particularly salient factor in cognitive and brain aging as it has been linked to decreased cognitive performance, a greater rate of brain shrinkage and degraded white matter integrity even in normal aging. Midlife elevations in blood pressure can predict a diagnosis of dementia later in the lifespan and older adults with an APOE ε4 allele and cardiovascular disease may be at greater risk for cognitive decline than those without such risk factors. Thus, the goal of the current analysis is to investigate the impact of hypertension in conjunction with the APOE polymorphism on one of the major biomarkers for Alzheimer’s disease, in vivo beta-amyloid deposition, within the ADNI sample, including mild cognitive impairment (MCI), dementia (AD) and normal control participants.
Additional Investigators