ADNI data is made available to researchers around the world. As such, there are many active research projects accessing and applying the shared ADNI data. To further encourage Alzheimer’s disease research collaboration, and to help prevent duplicate efforts, the list below shows the specific research focus of the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Yize Zhao |
| Institution: | Weill Cornell Medicine, Cornell University |
| Department: | Healthcare Policy and Research |
| Country: | |
| Proposed Analysis: | We propose to conduct joint analysis of multivariate phenotypes and ultra-high dimensional genotypes obtained from the Alzheimer's Disease Neuroimaging Ini- tiative (ADNI). However, the development of statistical and computational methods for such joint analysis present major computational and theoretical challenges for existing statistical methods. The aim of this and the subsequent projects is to propose a novel multilevel sequential selection procedure under a Bayesian multivariate response regression model (MRRM) to select informative features among multivariate responses and ultra high-dimensional predictors. Specically, we treat the identication of nonzero elements in the sparse coefficient matrix as a hierarchical feature selection problem by selecting potential nonzero rows among the matrix (genotype selection) and then localizing the nonzero elements within the marked rows (phenotype selection). The genotype-wise selection is accomplished by constructing multilevel auxiliary selection models under different scales with the actual scale auxiliary model treated as another level for the ultimate phenotype-wise selection. This procedure allows the posterior inference be "reweighted" to concentrate more efficiently on the potential signals in a sequential fashion, which dramatically reduces the computational cost and improves the mixing of Markov chain. |
| Additional Investigators |
