There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Gabriel Bucur |
| Institution: | Radboud University Nijmegen |
| Department: | Data Science |
| Country: | |
| Proposed Analysis: | We are interested in developing a Bayesian method for pleiotropy-robust Mendelian randomization. Our approach requires a full data set to fit the model and we would like to apply it on a real-world data set. For instance, we would like to estimate the causal effect of a biomarker like CSF amyloid beta-protein on the progression of Alzheimer's disease. By using genetic variants as instruments for the exposure / biomarker of interest, we want to show that our method produces reasonable output even when the exclusion restriction assumption of instrumental variables does not hold. |
| Additional Investigators |
