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Principal Investigator  
Principal Investigator's Name: Christian Langkammer
Institution: Medical University of Graz
Department: Neurology
Country:
Proposed Analysis: We are conducting an explorative longitudinal study including patients with AD and age-matched control subjects, which will be recruited for their 2 years follow-ups from our outpatient department and undergo extensive cognitive testing and quantitative 3 Tesla MRI. Regional differences of susceptibility (QSM) and R2* in deep gray matter and the neocortex will be evaluated in AD patients and controls and related to the patients´ cognitive status at baseline. Follow-up MRI and clinical data with multivariate regression analysis serve to investigate the dynamics of AD-related changes of susceptibility, and their relation to cognitive functioning. With this longitudinal study in a large patient cohort we aim to clarify whether regional iron deposition is a cause or merely epiphenomenon of AD and if changes of magnetic susceptibility can serve as a predictive marker for AD progression. We are currently investigating machine learning (deep learning) approaches for the classification of the above mentioned cohort of AD patients and HC - comparable to the CADDementia challenge and would like to (i) pool T1w structural data and (ii) compare the machine learning results in our cohort to AIBL and ADNI. For more details please see: http://www.neuroimaging.at/pages/research/longitudinal-qsm-in-alzheimers.php http://pf.fwf.ac.at/project_pdfs/pdf_abstracts/kli523e.pdf
Additional Investigators  
Investigator's Name: Christian Tinauer
Proposed Analysis: Mr Tinauer will conduct the same analysis as PI.
Investigator's Name: Christian Tinauer
Proposed Analysis: Heatmapping LRP