There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Oscar Harari |
| Institution: | Washington University in St Louis |
| Department: | Psychiatry |
| Country: | |
| Proposed Analysis: | Alzheimer's disease (AD) is the most common form of dementia but has no effective prevention or treatment. The brain proteome, ascertained in cerebrospinal fluid (CSF) have proven to be a rich source of information, reflecting Aβ plaques deposition, neurofibrillary tangles, neuronal injury and inflammation, and have helped the enrollment of participants in clinical trials. Still, additional non-invasive and cost-effective biomarkers are critical for the early detection, disease intervention and monitoring. Novel biomarkers may also help identify and characterize the additional aspects of AD, such as rate of progression and age at onset. Although genetic studies have focused on the identification of variants associated with risk through genome-wide association studies (GWAS) and whole genome and exome sequencing projects, the genetic factors modulating these additional aspects of AD are less investigated. The current proposal focuses on these understudied aspects of disease etiology, namely the role of common and rare genetic variation on quantitative diagnostic and prognostic endophenotypes of Alzheimer's disease (AD). I request access to the ADNI data repository to validate finding identified in the study of the Knight-ADRC dataset. This project will develop a unique resource - the proteome ascertained in a plasma and CSF for a large number of samples - that will allow to leverage unbiased approaches to reveal novel biomarkers and endophenotypes associated with AD. |
| Additional Investigators |
