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Principal Investigator  
Principal Investigator's Name: John Farrell
Institution: Boston University Medical School
Department: Biomedical Genetics
Country:
Proposed Analysis: The overall goal of this project is to delineate the complete genetic architecture of Alzheimer disease (AD). We plan apply various analytical methods to detect AD- related genes or other functional elements that harbor rare variants using the ADSP, ADNI and other AD cohort sequence data. We will use various pipelines to identify structural variants . A particular interest will be identifying LOF variants in known AD genes. We will also develop an imputation reference panel from the AD cohorts to impute into larger GWAS such as the ADGC and UK Biobank GWAS data sets.
Additional Investigators