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Principal Investigator  
Principal Investigator's Name: Kurt Farrell
Institution: Icahn School of Medicine at Mount Sinai
Department: Pathology
Country:
Proposed Analysis: Together with a group of neuropathologists, we have recently established consensus criteria for a new category of neuropathologic change, termed primary age-related tauopathy (PART). Individuals with PART display AD-type neurofibrillary tangles (NFT) in the medial temporal lobe in the absence of ABeta plaques. Patients with PART may have normal cognition, amnestic mild cognitive impairment (aMCI), or an amnestic dementia. Studies suggest that PART subjects have molecular and genetic features that provide resistance to cerebral amyloidosis but also vulnerability to neurofibrillary degeneration. The long-term goal of the PART working group is to characterize PART to enable new diagnostic and therapeutic strategies. Our objective is to validate the new criteria for PART, characterize its molecular signature, and perform a rigorous genetic analysis. Our hypothesis is that subjects with PART have distinct characteristics that underlie their NFT+/ABeta- phenotype. We are seeking to validate our current genetic finding and would like to probe the ADNI database to see if our prior work replicates in subjects found in your CSF and imaging studies with low Abeta. Our Current study only involves postmortem tissue and thus does not require IRB approval
Additional Investigators