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Principal Investigator  
Principal Investigator's Name: Navneet Hakhu
Institution: University of California, Irvine
Department: Statistics
Country:
Proposed Analysis: To quantify the impact of enrichment in AD trials on statistical operating characteristics (scientific estimand, bias, precision, power) when pre-post models (e.g., ANCOVA, t-test, generalized estimating equations) are utilized in the presence of model misspecification.
Additional Investigators  
Investigator's Name: Daniel Gillen
Proposed Analysis: To investigate the impact of enrichment in AD trials on statistical operating characteristics (scientific estimand, bias, precision, power) when pre-post models (e.g., ANCOVA, t-test, generalized estimating equations) are utilized in the presence of model misspecification.