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Principal Investigator  
Principal Investigator's Name: Lisa Graves
Institution: VA San Diego Healthcare System; UC San Diego
Department: Mental Health Service; Psychiatry
Country:
Proposed Analysis: Using data from the Alzheimer’s Disease Neuroimaging Initiative, we aim to examine associations among subjective reports of cognition and everyday functioning, objective performance on core neuropsychological (NP) indices and NP process scores, genetic data (e.g., ApoE status, family history of dementia or Alzheimer’s disease [AD]) and other biomarker variables (e.g., CSF amyloid and tau), and psychiatric and behavioral symptoms in cognitively healthy older adults (OA), OA diagnosed with mild cognitive impairment (MCI) based on comprehensive actuarial neuropsychological criteria (Bondi et al., 2014, Edmonds et al., 2015, 2016), and OA with dementia due to AD. Specifically, we aim to examine the influence of ApoE status and other genetic risk factors for AD on the onset and course of neurobiological processes associated with AD, subtle and frank cognitive impairment, behavioral changes, and functional decline across the spectrum of normal aging, MCI, and dementia due to AD using mixed effects model regression techniques. Additionally, we aim to examine the extent to which psychiatric symptoms and other lifestyle factors (e.g., depression, anxiety, sleep) may moderate these relationships and thereby influence risk for conversion to MCI and dementia due to AD in older adults. We believe that addressing these aims will enhance our understanding of the interplay among genetic/biological and psychosocial risk factors, neurobiological processes, and cognitive and functional changes associated with AD, as well as identify potential targets for intervention in older adults at risk for AD.
Additional Investigators