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Principal Investigator  
Principal Investigator's Name: Tengfei Guo
Institution: University of California, Berkeley
Department: Helen Wills Neuroscience Institute
Country:
Proposed Analysis: To investigate the spatial patterns of amyloid, tau and neurodegeneration in different AT(N) profiles, we plan to focus on the cognitively unimpaired and impaired elderly ADNI participants with amyloid PET, tau PET, FDG PET, structural MRI images and CSF biomarkers. Region of interesting and voxel-wise analyses will be done to create spatial patterns of amyloid, tau and neurodegeneration in different AT(N) stages. We aim to understand the temporal sequences of amyloid, tau and neurodegeneration on the AD continuum and the relationships between amyloid, tau and neurodegenetaion in AT(N) research framework.
Additional Investigators  
Investigator's Name: Dai Shi
Proposed Analysis: Dr. Shi is going to focus amyloid and tau PET image analyses.
Investigator's Name: Anqi Li
Proposed Analysis: Anqi will analyses the associations of amyloid and tau with cognition using ADNI data
Investigator's Name: Guoyu Lan
Proposed Analysis: Guoyu will analyze synaptic biomarkers of Alzheimer's disease to study the abnormal changes of synaptic protein.
Investigator's Name: Yue Cai
Proposed Analysis: Dr. Cai will analyze the association between synaptic dsyfunction and structural connectivity in AD
Investigator's Name: Pan Sun
Proposed Analysis: Dr. Sun will analyze amyloid PET, tau PET, FDG PET and MRI images to explore the earliest abnormal changes of AD pathologies.