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Principal Investigator  
Principal Investigator's Name: Omar Butt
Institution: Washington Univeristy in Saint Louis
Department: Neurology
Country:
Proposed Analysis: Explore evolution in resting state signals between key networks and regions in preclinical individuals as a function of genotype/APOE allele status; essentially building on Shi et al 2020 in an earlier subgroup, then expanding on it to include an evaluation of concurrent biomarkers and other imaging modalities/imaging biomarkers.
Additional Investigators  
Investigator's Name: Jeremy Strain
Proposed Analysis: Explore longitudinal imaging correlates with cognitive function
Investigator's Name: Patrick Luckett
Proposed Analysis: Explore evolution of WM signal change over time in ADAD
Investigator's Name: Karin Meeker
Proposed Analysis: Working with Jeremy Strain and Patrick Luckett
Investigator's Name: Beau Ances
Proposed Analysis: PI overseeing Omar Butt, Jeremy Strain Patrick Luckett, Karin Meeker, Nick Metcalf Dimitre Tomov, Haleem Azmy, Sarah Cooley, Anna Boerwinkle Collin Kilgore and Peter Millar. Broadly speaking exploring application of multimodal imaging to understand evolution of key imaging features during the preclinical phase of ADAD.
Investigator's Name: Nick Metcalf
Proposed Analysis: Working with Jeremy Strain and Patrick Luckett
Investigator's Name: Dimitre Tomov
Proposed Analysis: Staff scientist in Ances lab who optimizes and standardizes pre-processing code for furher analyses conducted by the post-docs in the Ances lab
Investigator's Name: Haleem Azmy
Proposed Analysis: Research Technician working with the post-docs in the Ances lab
Investigator's Name: Sarah Cooley
Proposed Analysis: Research Technician working with the post-docs in the Ances lab
Investigator's Name: Anna Boerwinkle
Proposed Analysis: Research Technician working with the post-docs in the Ances lab
Investigator's Name: Collin Kilgore
Proposed Analysis: Research Technician working with the post-docs in the Ances lab
Investigator's Name: Peter Millar
Proposed Analysis: Gradiate student working in the Ances lab; To explore variance in resting-state signals in key regions and networks in preclinical ADAD