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Principal Investigator  
Principal Investigator's Name: Yifan Fang
Institution: Zhongnan hospital
Department: department of neurology
Country:
Proposed Analysis: Recent studies have investigated potential factors that influcence treatment response to AChE in patients with AD, yet with inconsistent outcomes.Some says higher hippocampus volume was associated with slower cognitive decline, some says others. While a number of studies have only taken one single factor into considerations,which might cause this inconsistency, we proposed that the treatment effect of AChE was multifactorial(i.e. the white matter lesions, the brain atrophy and the cholinergic system), and try to demonstrate it by changes in neural activations owing to previous studies. Thus the MRI data, the biochemical and neuropsychological results are urgently needed. The following part of this study will be conducted according to the analysis. I sincerely hope to get your approval.Please contact me if any detailed information is needed.
Additional Investigators