There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Ahmad Aziz |
| Institution: | German Center for Neurodegenerative Diseases |
| Department: | Population Health Sciences |
| Country: | |
| Proposed Analysis: | Neuroaxonal damage is a shared and early feature of neurodegenerative diseases, including Alzheimer disease. Neurofilament light chain (NfL) levels in blood have recently emerged a sensitive preclinical maker of neuroaxonal damage. Nevertheless, little is known about the genetic and epigenetic determinants of NfL levels. Therefore, we aim to perform genome- and epigenome-wide association studies of blood NfL levels in a large-scale population-based cohort study. We aim to use (genomic and epigenetic) data from ADNI for replication and external validation of our findings in a fully independent cohort. |
| Additional Investigators |
