There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Katie Chan |
| Institution: | City University of Hong Kong |
| Department: | Biomedical Sciences / Electrical Engineering |
| Country: | |
| Proposed Analysis: | 1) identify shared and ethnic-specific biological pathways and gene networks between complex traits e.g. diabetes and Alzheimer's diseases 2) evaluate the modification of medication use on biomarker-related genetic variants with risk of complex traits 3) assess the causal association between biomarkers and risk of complex traits using mendelian randomization approach 4) identify shared and ethnic-specific biological pathways and gene networks that are perturbed by genetic risks of complex traits between ethnic groups 5) identify shared and ethnic-specific gene network x environmental risk factors interactions that contribute to risk of complex traits between ethnic groups 6) identify shared and ethnic-specific biological pathways and gene networks that are perturbed by genetic effect of medication use between ethnic groups. 7) assess the association between potential biomarkers targeted by medication use and risk of complex traits using Mendelian Randomization with medication related genetic loci as instruments 8) build diseases risk prediction models 9) identify omics variants related to demographic, lifestyle, biomarkers, and environmental risk factors of complex traits 10) assess the association between early life factors with risk of complex traits 11) apply various methodologies e.g. mendelian randomization, mediation, polygenic score, etc. to investigate the molecular and physiologic mechanism of complex traits 12) incorporate various types of data e.g. genomics, demographic, lifestyle, biomarkers, questionnaire as well as imaging data to improve the understanding of complex traits |
| Additional Investigators |
