There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Carmel Armon |
| Institution: | Tel Aviv University School of Medicine /Shamir (Assaf Harofeh) Medical Center |
| Department: | Neurology |
| Country: | |
| Proposed Analysis: | Provided you have collected the data: I propose to estimate the X chromosome-mediated risk for developing LOAD by looking at the subgroup of patients with aMCI or LOAD and unilateral ancestral history of AD or dementia by analyzing their numbers (a-d) defined as follows: Probands Paternal side Maternal side affected affected Women a b Men c d The odds ratio OR= (a:b)/(c:d) estimates the relative risk conferred by the X chromosome, controlling for confounders. The estimated proportion of risk mediated by the X chromosome is calculated as (OR-1)/)OR. Abstract describing preliminary application of this method accepted for presentation at the Virtual Annual meeting of the European Society for Human Genetics, June 12-15. My objective is to apply the method to a well defined group of patients with aMCI or AD, and a FH obtained via a consistent, uniform protocol. If the primary analysis described above yields a meaningful effect size, and the numbers are sufficiently large, I may seek to conduct exploratory subgroup analyses, based on co-variates such as ApoE status. |
| Additional Investigators | |
| Investigator's Name: | Sharon Wolfson |
| Proposed Analysis: | Same as before. She is my research assistant. |
