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Active Investigations

There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.

Principal Investigator  
Principal Investigator's Name: Breanna Harris
Institution: Texas Tech University
Department: Biological Sciences
Country:
Proposed Analysis: Stress and stress-related biomarkers are correlated with cognitive decline and Alzheimer’s Disease (AD) pathogenesis. Thus, these parameters may serve as preclinical markers for AD. We plan to investigate the relationship among stress-associated biomarkers and single-nucleotide polymorphisms (SNPs) in ADNI1 study participants (n=818). Specifically, we are requesting: • 39 stress- and cognition-association SNPs (37 from the Illumina Human 610-Quad bead chip and 2 APOE genes), and biomarkers of cumulative stress (body mass, systolic and diastolic blood pressure, pulse, and homocystine) measured at both baseline and 24-month follow up. We plan to use structural equation modeling to estimate relations among these biological measures and various cognitive measures (see immediately below). • Scores from the following cognitive assessments (measured at baseline and 24-month follow up): American National Adult Reading Tests, Mini Mental Status Examination, Logical Memory 1 and 2, Everyday Cognition, Montreal Cognitive Assessment, Digit Span, Category Fluency, Category Fluency Animals, Trails Test, Digit Symbol, Boston Naming Test, Auditory Verbal Learning Test, Clock Drawing, ADAS-cog, ADAS-cog13, Clinical Dementia Rating Scale. • Cerebrospinal fluid Tau, AB1-42 and P-tau181P data to compare levels of these AD-associated proteins with stress-associated biomarkers. • If plasma or serum exists for the ADNI1 cohort at baseline, we would like to request access to aliquots (325 ul) for analysis of circulating cortisol and catecholamines, two important stress-related hormones. Based on a search of the ADNI literature database, this is a novel proposal and its completion will provide much needed information on novel AD biomarkers.
Additional Investigators