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Principal Investigator  
Principal Investigator's Name: Byron Creese
Institution: King's College London
Department: University of Exeter Medical School
Proposed Analysis: We will test the hypothesis that a polygenic risk score generated from the Psychiatric Genetics Consortium (PGC) schizophrenia data set predicts psychosis (delusions or hallucinations) in Alzheimer's disease. We have the genome-wide summary statistics from PGC and also clinical and genome-wide data from the European AddNeuroMed cohort. The clinical data consists of longitudinal evaluations of psychosis using the Neuropsychiatric Inventory and cognitive assessments by MMSE. These were carried out every three months for one year. In order to test our hypothesis robustly we intend to run the analysis in this cohort and in a replication cohort. To this end, we would like to request equivalent data (as well as demographic data) from the ADNI cohort due to the similar protocol used. If assessments were not done every three months we would like to request the most complete longitudinal data that is held. We will code Alzheimer's cases based on the number of psychotic episodes during the length of follow up as follows: 0=no psychosis in follow up; 1=one episode of psychosis; 2=more than one episode of psychosis. Two principal analyses will be conducted. The first will examine the predictive value of the polygenic score in individuals with any psychosis (that is, 0 vs 1 and 2). The second will test the polygenic score in only individuals with multiple episodes of psychosis (that is, 0 vs 2). We will also test the relationship in a control group of cognitively normal individuals so would like to request these individuals from ADNI, if available.
Additional Investigators