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Principal Investigator  
Principal Investigator's Name: Pradyumna Bharadwaj
Institution: The University of Arizona
Department: Psychology
Proposed Analysis: The objective of this project is to characterize cognitively unimpaired healthy older adults by incorporating information from three complementary sources: Assays of proteins closely associated with Alzheimer's Disease (AD), Reports of subjective memory status, and Non-invasive structural and resting state functional magnetic resonance imaging (MRI). Together, these elements may provide additive information about preclinical Alzheimer’s Disease risk beyond single biomarkers, genetic risk, or scores on objective memory tests. We propose to examine the relation between AD-related proteins, and data derived from structural and functional MRI within a multivariate network analysis framework, and evaluate this relationship in the context of differences in subjective memory status. The impact of genetic, cardiovascular disease risk, and other relevant demographic, and health factors on this association will be evaluated as well. This approach may provide a more comprehensive and robust account of the brain differences in at-risk cognitively normal individuals, and expand our understanding of preclinical AD.
Additional Investigators