There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Charles Pace |
| Institution: | New York University/Student |
| Department: | Psychology |
| Country: | |
| Proposed Analysis: | I would like to combine patient structural neuroimaging and metabolic data to use as features in a model predicting degrees of cognitive impairment. In particular, I would like to explore whether structural changes in hippocampal size, such as volume reduction, can be incorporated into a model with variables relating to metabolic dysfunction including homeostatic assessment of insulin resistance (HOMA-IR), body-mass-index, waist-to-height ratio, lipid profile, and CRP levels, blood pressure, to predict cognitive dysfunction in relation to Alzheimer's disease. Hippocampal atrophy has been associated with cognitive decline. HOMA-IR has been associated with total hippocampal volume, cognitive decline, and Alzheimer's disease. In the process, I would like to work on developing machine learning models for the segmentation of the hippocampus and identification of hippocampal volume reduction. |
| Additional Investigators |
