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Participant Pool:
  • 200 Normal Controls
  • 400 MCI
  • 200 Mild AD
  1. Develop improved methods that create uniform standards for acquiring longitudinal, multi-site MRI and PET data on patients with Alzheimer’s disease (AD), mild cognitive impairment (MCI), and elderly controls.
  2. Acquire a generally accessible data repository which describes longitudinal changes in brain structure and metabolism as well as clinical/cognitive and biomarker data for the validation of imaging surrogates.
  3. Develop methods which will provide maximum power to determine treatment effects in trials involving these patients.
  4. Test a series of hypotheses based on the clinical and biomarker data.