There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Thomas Jacquemont |
| Institution: | Institut du Cerveau et de la Moelle |
| Department: | Equipe ARAMIS |
| Country: | |
| Proposed Analysis: | Characterization of the preclinical and prodromal stages of Alzheimer’s disease (AD) is important for the design, evaluation and implementation of new therapies. In 2010, Jack et al have proposed an hypothetical model of the temporal ordering of biomarker abnormalities, suggesting that amyloid markers become abnormal first, followed by tau markers, structural neuroimaging, memory and clinical function. Recently, experimental evidence has suggested that a substantial fraction of subjects display abnormal markers of neurodegeneration without amyloidosis, a category termed as SNAP – suspected non-amyloid pathology. For this proect, I propose to characterize the SNAP population in terms of structural brain networks. This interest is based on cumulative evidence that signatures of network disintegration differentiate neurodegenerative diseases and reflects topographical patterns of abnormal protein accumulation. I will compare subjects with mild cognitive impairment (MCI) and SNAP to subjects with MCI and amyloidosis using white matter tractography from diffusion-weighted MRI. Subjects will be extracted from the publicly available databases ADNI-GO and ADNI-2 |
| Additional Investigators |
