There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Magdalena Machnicka |
| Institution: | University of Warsaw |
| Department: | Faculty of Mathematics, Informatics and Mechanics |
| Country: | |
| Proposed Analysis: | The aim of our research is to identify regulatory variants associated with the early-onset Alzheimer's disease. We plan to perform targeted next generation sequencing of the regulatory regions of genome for a cohort of 24 patients. We will use a set of regulatory regions that we identified to be active in human brain. We would like to compare the set of regulatory variants identified in our cohort to the whole genome sequencing results collected by ADNI and screen these results for other possible regulatory variants. |
| Additional Investigators | |
| Investigator's Name: | Bartosz Wilczyński |
| Proposed Analysis: | This Co-Investigator will participate in two types of analysis: 1. The analysis which aim is identification of regulatory variants associated with the early-onset Alzheimer's disease. We plan to perform targeted next generation sequencing of the regulatory regions of genome for a cohort of 24 patients. We will use a set of regulatory regions that we identified to be active in human brain. We would like to compare the set of regulatory variants identified in our cohort to the whole genome sequencing results collected by ADNI and screen these results for other possible regulatory variants. 2. Development of machine-learning algorithms for identification and classification of patients with dementia based on single nucleotide polymorphisms detected in whole-genome sequencing data. |
