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Principal Investigator  
Principal Investigator's Name: Makoto Ishii
Institution: Weill Cornell Medical College
Department: Neurology
Country:
Proposed Analysis: Altered Metabolic Signaling in Alzheimer's Disease and Related Disorders Aim 1: To determine whether alterations in analytes found in plasma and CSF samples of mice models of AD are found in the ADNI study population. Aim 2: To determine whether alterations in analytes found in plasma and CSF samples of a human preclinical AD study population are also found in the ADNI study population. Aim 3: To determine whether alterations in plasma/CSF levels of metabolic hormones (e.g., insulin, leptin etc) correlate with alterations in CSF and neuroimaging AD biomarkers in ADNI study population.
Additional Investigators  
Investigator's Name: Alice Tao
Proposed Analysis: Altered Metabolic Signaling in Alzheimer's Disease and Related Disorders Aim 1: To determine whether alterations in analytes found in plasma and CSF samples of mice models of AD are found in the ADNI study population. Aim 2: To determine whether alterations in plasma/CSF levels of metabolic hormones correlate with alterations in CSF and neuroimaging AD biomarkers in ADNI study population. Aim 3: To determine if alterations in brain regions involved in systemic metabolism and its connections are found in ADNI study population.
Investigator's Name: Emily Eruysal
Proposed Analysis: Altered Metabolic Signaling in Alzheimer's Disease and Related Disorders Aim 1: To determine whether alterations in analytes found in plasma and CSF samples of mice models of AD are found in the ADNI study population. Aim 2: To determine whether alterations in plasma/CSF levels of metabolic hormones correlate with alterations in CSF and neuroimaging AD biomarkers in ADNI study population. Aim 3: To determine if alterations in brain regions involved in systemic metabolism are found in ADNI study population.
Investigator's Name: Harshil Bhavsar
Proposed Analysis: Altered Metabolic Signaling in Alzheimer's Disease and Related Disorders Aim 1: To determine whether alterations in analytes found in plasma and CSF samples of mice models of AD are found in the ADNI study population. Aim 2: To determine whether alterations in plasma/CSF levels of metabolic hormones correlate with alterations in CSF and neuroimaging AD biomarkers in ADNI study population. Aim 3: To determine if alterations in brain regions involved in systemic metabolism are found in ADNI study population.
Investigator's Name: Lina AL-Ani
Proposed Analysis: Altered Metabolic Signaling in Alzheimer's Disease and Related Disorders Aim 1: To determine whether alterations in analytes found in plasma and CSF samples of mice models of AD are found in the ADNI study population. Aim 2: To determine whether alterations in analytes found in plasma and CSF samples of a human preclinical AD study population are also found in the ADNI study population. Aim 3: To determine whether alterations in plasma/CSF levels of metabolic hormones (e.g., insulin, leptin etc) correlate with alterations in CSF and neuroimaging AD biomarkers in ADNI study population.
Investigator's Name: Nada Abdallah
Proposed Analysis: Altered Metabolic Signaling in Alzheimer's Disease and Related Disorders Aim 1: To determine whether alterations in analytes found in plasma and CSF samples of mice models of AD are found in the ADNI study population. Aim 2: To determine whether alterations in analytes found in plasma and CSF samples of a human preclinical AD study population are also found in the ADNI study population. Aim 3: To determine whether alterations in plasma/CSF levels of metabolic hormones (e.g., insulin, leptin etc) correlate with alterations in CSF and neuroimaging AD biomarkers in ADNI study population.