Question Posted 10/29/14:
How do neurons die in Alzheimer's disease? What is the mechanism of cell death?
Response posted 10/29/14 by michael weiner:
This is a complicated question, which is beyond the scope of ADNI, a clinical study. In brief, Alzheimer's disease is charachterized by the accumulation of two proteins: beta amyloid and tau. The accumulation of tau tangles is associated with neurodegeneration. The specific mechanisms of cell death are being investigated in animal models