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ADNI 4

ADNI4 builds on the extensive history of the study but aims to make ADNI data more broadly relevant and generalizable to the North American population. To achieve this, ADNI is aiming to increase the participation of individuals from underrepresented populations (URPs), with an ambitious goal of 50-60% of new participants enrolled from URP backgrounds (ethnocultural diversity; education of 12 years or fewer). ADNI4 continues to aid in the discovery, optimization, standardization, and validation of clinical trial measures and biomarkers used in AD research. ADNI4 began enrolling participants in 2023.

What's new in ADNI4?

Clinical Cohort

New assessments to help understand social determinants of health including:

New Assessments
New
Assessments
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Hollingshead Index, Area Deprivation Index, Rural-Urban Commuting Area codes (RUCA), Rural-Urban Continuum Codes (RUCC), Perceived Ethnic Discrimination Questionnaire (PEDQ), Perceived Stress Scale (PSS), Abbreviated Multidimensional Acculturation Scale (AMAS) (for those who identify as Latino) 
Amyloid + Tau PET Insight
Amyloid + Tau
PET Insight
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Participants will undergo both amyloid and tau PET scans. All participants have the option to learn their amyloid PET results
Expanded plasma biomarker data
Expanded Plasma Biomarker Data
New Genetic Data
New
Genetic Data
New MRI sequences
New
MRI Sequences
Digital Neuropathology
Digital
Neuropathology
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digitized slides (images) of specific brain regions, available for approved ADNI data users to download

Remote Cohorts

Remote Digital Cohort

ADNI4 also incorporates novel “remote cohorts” which includes screening participants from their home and referring those likely to be eligible to participate in the ADNI4 clinical based study to their local site.

The results from the participants in these remote cohorts will also be shared on the LONI data repository.

Data collected from participants completing online questionnaires and cognitive testing (Remote Digital Cohort), coupled with blood-based biomarkers (Remote Blood Cohort), will identify individuals who will be referred to ADNI4 clinical sites for in-depth clinical, imaging, genetic, and biochemical biomarker characterization.

In-clinic participants in the cognitively unimpaired (CU) and mild cognitive impairment (MCI) arms of the study are invited to complete cognitive assessments through an online portal.

ADNI4 In-Clinic Participant Pool:

ADNI4 includes scientists at more than 60 research centers in the United States and Canada
and will enroll up to 1500 subjects (elderly controls, MCI, AD/dementia):
ADNI Target Cohort
ADNI Participating Sites

ADNI Recruitment Flow

ADNI4 Recruitment Flow
2024 Alzheimer’s Disease Neuroimaging Initiative
This website is funded by the Alzheimer’s Disease Neuroimaging Initiative