Clinical Core
The Clinical Core is co-directed by Paul Aisen, M.D., Professor of Neurology and Director of the Alzheimer’s Therapeutic Research Institute at the University of Southern California (USC), and Ronald Petersen, M.D., Ph.D., Professor of Neurology and Director of the Mayo Clinic’s Alzheimers Disease Research Center and the Mayo Clinic Study of Aging. The Clinical Core/Coordinating Center is based at the Alzheimer’s Therapeutic Research Institute (ATRI) at USC and manages the day-to-day clinical operations of ADNI. The Clinical Core oversees all clinical activities and contracts, manages clinical site-generated data systems including data tracking and quality control, aids in the recruitment and retention of participants, provides regulatory oversight, oversees financial management of site costs, conducts safety monitoring (including DSMB reporting), and creates the final “locked dataset” for each phase of the ADNI study.
For ADNI4, the participant amyloid disclosure process was designed in collaboration with Jason Karlawish, M.D., Claire Erickson, Ph.D., Joshua Grill, Ph.D., Kristin Harkins, MPH, and Emily Largent, Ph.D..
