The ADNI study uses a set of standardized protocols to allow comparison of results from multiple data collection centers (clinical sites), which make the data incredibly valuable to researchers. A number of other initiatives related to AD and other diseases have been designed and implemented using ADNI as a model.
ADNI-D
Through dynamic partnerships with the Alzheimer’s Disease Neuroimaging Initiative (ADNI-II) and industry sponsorship, the ADNI-D study is well positioned to successfully address the impact of reduced cerebral blood flow (hypoperfusion), cortical atrophy, and amyloid deposition on cognitive impairment and accelerated cognitive decline in Late Life Depression (LLD) in the context of previously documented relationships between cognitive impairment and subcortical white matter abnormalities and genetic risk factors. ADNI-D is focused on establishing improved diagnostic approaches and targeted treatment trials aimed at LLD and cognitive impairment (CI) associated with LLD, ultimately leading to improved health outcomes and reduced healthcare costs.
Study Design
This is a non-randomized non-treatment study. One hundred and twenty (120) subjects who meet criteria for Major Depression or LLD will be enrolled for a period of 30 months. Data from an additional 300 non-depressed subjects will be used from the previous ADNI studies for comparison. Depression history, symptom severity, and health information will be collected at the initial psychiatric visit to determine eligibility. A 3T MRI and18F-AV-45 amyloid imaging will be conducted at the ADNI site for the initial clinical visit. Collection of plasma and serum for biomarkers, clinical assessments, and cognitive assessments will be conducted at both time points. Blood samples will also be collected for genetic analysis.
Objectives:
DOD-ADNI
Veterans with traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) appear to have a greater associated risk of Alzheimer’s disease and dementia. The purpose of DOD ADNI is to examine the possible connections between TBI and PTSD, and the signs and symptoms of Alzheimer’s disease on Veterans as they age. The results of the DOD ADNI study will lead to greater efforts to develop treatment and prevention studies to help reduce these long-term effects of TBI and PTSD injuries. Funded by the Department of Defense (DOD), this study is the first step towards a larger, more comprehensive study of dementia risk factors in Veterans.
Study Design
Vietnam War Veterans between the ages of 60-80 years will be identified and contacted using Veterans Affairs records. The enrollment goal is 195 participants divided into three study groups. This study excludes mild cognitive impairment (MCI) and dementia subjects.
Objectives:
Worldwide ADNI
WW-ADNI is a collaborative effort of scientists from around the world convened by the Alzheimer’s Association and is the umbrella organization for neuroimaging initiatives being carried out globally. World Wide ADNI (WW-ADNI) unites leading international investigators in a common effort to:
Each WW-ADNI site collects clinical and biomarker data from participants. Biomarker data may include imaging data (MRI, PET) or fluid biomarker data (CSF, plasma). WW-ADNI has a goal of making most of the clinical, neuropsychological, imaging, and biological data gathered available to the scientific community.
The Active WW-ADNI Sites include:
If you are 55 to 90 years of age you may be able to participate. Participation is free and no medication is involved.
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