Alzheimer’s Disease Neuroimaging Initiative

Question

Question Posted 01/26/26:
Dear Team,

We have been trying to find the cerebellum segmentation values for each patient through Cross-Sectional FreeSurfer 5.3 or higher. We currently have Cross-Sectional FreeSurfer 7.x downloaded. How should we proceed? Would the data be more accessible in a different version of FreeSurfer?

Thank you,
Sanjana Vaddi

Response posted 01/26/26 by KC:

All of the Cross-Sectional FreeSurfer (7.x) variables are described in the Data Dictionary, including those related to volume of cerebellum. We suggest you download the data dictionary and the "UCSF - Cross-Sectional FreeSurfer (7.x)" data. You may also use ARC Builder to search for variables and see the measure values.

Response posted 03/13/26 by Sanjana Vaddi:

Dear team,

Is the SUVr data normalized to the values for the volume of the cerebellum listed in Cross-Sectional FreeSurfer (7.x)?

Thank you,
Sanjana Vaddi

Response posted 03/13/26 by Susan:

SUVrs are ratios that represent mean tracer uptake in a region of interest (for example, entorhinal cortex) relative to mean tracer uptake within a reference region (for example, cerebellar grey matter). The normalization involves mean tracer uptake measured on a PET scan, and does not involve volume assessed by FreeSurfer. However, we use FreeSurfer regional data to define the boundaries of the regions we are measuring PET tracer uptake from. All of the methods used to calculate SUVrs for the UC Berkeley ADNI PET data are described in Methods documents found alongside the PET datasets (in Study Data), and the methods are also described in detail here: https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.14378

Go back to list of topics >