Question
Question Posted 06/11/13:
When following strictly the neuropsychological scores of the inclusion criteria of ADNI 2, some LMCI subjects would be classified as EMCI, some as AD. E.g. subject 007_S_4611 with 18 years of education, logical memory (LM) score of 1, MMSE of 25 and CDR is 0.5 would be most likely labeled as AD because of the low LM and MMSE scores, but is actually LMCI.
Therefore, I would like to know how much impact other information such as subjective memory complaint or the NINCDS/ADRDA criteria have on the final diagnosis? And whether there is the possiblity that the labels have not been updated correctly?
When following strictly the neuropsychological scores of the inclusion criteria of ADNI 2, some LMCI subjects would be classified as EMCI, some as AD. E.g. subject 007_S_4611 with 18 years of education, logical memory (LM) score of 1, MMSE of 25 and CDR is 0.5 would be most likely labeled as AD because of the low LM and MMSE scores, but is actually LMCI.
Therefore, I would like to know how much impact other information such as subjective memory complaint or the NINCDS/ADRDA criteria have on the final diagnosis? And whether there is the possiblity that the labels have not been updated correctly?
Response posted 06/11/13 by Melissa Davis:
The LMCI and AD criteria overlap somewhat. Both LMCI and AD have the same range for logical memory. AD criteria for MMSE is 20-26 and LMCI is 24-30. This participant's score (25) fits in both categories. Similar with CDR - LMCI requires at least 0.5 on global and memory box; AD is CDR>=0.5. LMCI inclusion criteria requires that participant's general cognition and functional performance is sufficiently preserved, whereas for AD cohort, the participant must meet NINCDS/ADRDA criteria for probable AD. The diagnostic group came down to clinician judgment on general cognition/functioning/probable AD diagnosis.
