For Researchers who are interested in working with numerical summary tables rather than raw image data, ADNI has funded the following MRI core analysis labs to generate numeric summaries from the high-quality MRI data available in the data archive.
Below is a List of the MRI analysis methods. Anyone with an ADNI Data Archive account may view and download the analysis methods and the analyzed data. After logging in, click Download and Study Data to see all relevant ADNI documents available for download. View more on MRI Numeric Outputs page.
2004 – 2009
2010 – 2016
2016-2022
2022 and beyond
The ADNI1 Protocol also included a phantom scan, with localizer and MP-RAGE scans available. For the phantom MP-RAGE scans, slice thickness was increased to cover the phantom.
Every participant scan undergoes a local clinical read by an on-site radiologist/clinician at the MRI facility. Scan interpretations for diagnostic clinical purposes will not be provided by the MRI Core for ADNI4. However, medical MR findings are recorded and available as part of the quality control done by the ADIR Lab. These findings include identification of infarctions, evidence of prior surgery or TBI, MPH/CSF dynamics disorders, cerebral microbleeds, superficial siderosis, and other vascular abnormalities such as DVAs and prior parenchymal hemorrhage. It should be noted that clinical findings may also be indicators of complications of therapy such as CMBs (ARIA-H), vasogenic edema (ARIA-E), or MPH-like effects on CSF dynamics.
For researchers interested in the imaging process as a whole, imaging files are available at every stage of pre- and post-processing. However, most researchers will prefer to use the scans that have undergone the maximum level of correction. For ADNI1 and early ADNI2, the MPRAGE files that have undergone gradwarping, intensity correction, and have been scaled for gradient drift using phantom data are recommended for use. For all ADNI4 data, it is recommended to use the chosen scan selected during the QC process.
Scans from ADNI1 have standardized data sets that require additional information to us, please see the MRI Image Data page.
Frequently Asked Questions: FAQs
MRI Core Ask the Experts: MRI Core Ask the Experts
ADNI MRI Core at Mayo Clinic (ADIR Lab): adnimri@mayo.edu
The MRI Core is responsible for all aspects of MRI imaging in ADNI, including determining specific MRI pulse sequence types and parameters for the ADNI protocol, which is updated every ADNI grant cycle, site qualification, protocol compliance, QA/QC of all MRI data, tracking all MRI data acquisition, processing, and performance of all MRI data processing.
The MRI Core will also utilize an array of ADNI data, including neuropsychological test results, genotyping, MRI morphometry and other biomarkers to investigate brain-behavior relationships in older adults with and without cognitive impairment.