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SMC – Significant Memory Concern


ADNI 2 added a new cohort, the Significant Memory Concern (SMC).  Subjective memory concerns have been shown to be correlated with a higher likelihood of progression, thereby minimizing the stratification of risk among normal controls and addressing the gap between healthy elderly controls and MCI.

The key inclusion criteria that distinguish the SMC cohort are a self-report significant memory concern from the participant, quantified by using the Cognitive Change Index and the Clinical Dementia Rating (CDR) of zero. SMC participants score within the normal range for cognition, and the informant does not equate the expressed concern with progressive memory impairment