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Principal Investigator  
Principal Investigator's Name: Byoung Seok Ye
Institution: Chuncheon national hospital
Department: Neurology
Proposed Analysis: There is an agreement among the clinicians that mild cognitive impairment (MCI) represents a useful clinical entity for predicting dementia. Because the patients with MCI perform their activities of daily living (ADL) without dependence, despite of their cognitive deficits, the diagnosis of MCI usually depends on the neuropsychological tests to verify the cognitive deficits. Based on the patterns of the cognitive deficits, MCI has been classified into the amnestic or non-amnestic MCI, and then subdivided into single-domain or multiple-domain MCI. There have been several studies suggesting amnestic MCI (aMCI) as a risk factor for developing or as a prodromal stage of Alzheimer’s disease (AD). Among the subtypes of MCI, the patients with multiple-domain amnestic MCI (M-aMCI) had higher rate of conversion to AD than single-domain amnestic MCI (S-aMCI). Our previous study with cortical thickness in the patients with S-aMCI and M-aMCI suggested a hierarchial order that M-aMCI is a transitional state on the progression of S-aMCI to AD. The memory tests entertained in the diagnosis of MCI can be categorized into either verbal or visual tests. According to the patterns of memory impairment on these memory tests, the patients with aMCI are subdivided into a verbal-aMCI, a visual-aMCI, or a dual-aMCI. Among the previous studies, the one study using verbal memory test revealed high conversion rate (more than 40%) to AD after one year, while other study using visual memory test showed low conversion rate of 11% over three years and high reversion rate to normal cognition (more than 40%). Although there has been a study that examined the difference in discrimination rates and conversion rates to AD among three common memory tests, it has focused on an each individual memory test and did not classified the aMCI patient according to the memory patterns. When considering the observation that estabilished AD patients show a pattern of combined verbal and visual memory deficit, it could inferred that dual-aMCI would have higher possibility of conversion to AD than both verbal-aMCI and visual-aMCI, regardless of the impairment in other cognitive domains (multiple aMCI or single aMCI). To our knowledge, there were not enough studies investigating the different fates of patients with aMCI according to the patterns of involved memory dysfunction. We aimed to reveal the rates of conversion, retention, and reversion, between the visual-aMCI, verbal-aMCI, and dual-aMCI.
Additional Investigators