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Principal Investigator  
Principal Investigator's Name: Joseph Giorgio
Institution: University of Cambridge
Department: Psychology
Country:
Proposed Analysis: We propose to implement machine learning algorithms with “privileged information” (PI). To address the twin need for (1) training robust models with a comprehensive set of inputs and (2) future prediction based on clinic data alone, we will train metric learning algorithms to classify individuals at high vs. low risk of dementia using multimodal MRI (i.e. structural and functional integrity and connectivity measures) as PI. These data provide prognostically relevant information above and beyond that obtainable from standard clinical practice tools. Following this training phase, the algorithms will be tested in classifying new individual cases from “routine” epidemiological and cognitive data alone that are typically collected at the clinic. This approach has the potential to deliver low-cost robust and sensitive tools of detecting individualized risk of disease that is scalable for widespread implementation in clinical practice.
Additional Investigators  
Investigator's Name: zoe kourtzi
Proposed Analysis: same as primary investigator
Investigator's Name: Avraam Papadopoulos
Proposed Analysis: Same as principal investigator
Investigator's Name: Soroosh Afyouni
Proposed Analysis: Same as principal investigator
Investigator's Name: Georgios Batzolis
Proposed Analysis: Same as principal investigator