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Principal Investigator  
Principal Investigator's Name: Baptiste Couvy-Duchesne
Institution: Institute of Molecular Bioscience
Department: Program for complex trait genetics
Country:
Proposed Analysis: We aim at identifying factor influencing advanced brain aging. To do this, we have used the UK Biobank imaging data to construct a predictor of brain age from T1 and T2 structural scans. We would like to apply this score in the AIBL, ADNI and ADNIDOD datasets. The difference between predicted brain age and real age of the participants will be used to quantify advanced brain aging. We will correlate this difference to a range of phenotypes available in all or part of the samples (e.g. physical activity, Alzheimer's status, history of mental health, cognition...). Do to the limited power of such design, we would need the largest sample available, which is why we request access to AIBL, ADNI and ADNIDOD.
Additional Investigators  
Investigator's Name: Jian Yang
Proposed Analysis: Analyse the genetic data in conjunction with the disease and biomarker variables. The objectives are to enrich the current genetic analyses of neurological traits as well as to apply and evaluate genetic prediction scores to the ADNI sample.
Investigator's Name: Qian Zhang
Proposed Analysis: Analyse the genetic data in conjunction with the disease and biomarker variables. The objectives are to enrich the current genetic analyses of neurological traits as well as to apply and evaluate genetic prediction scores to the ADNI sample.
Investigator's Name: Naomi Wray
Proposed Analysis: Analyse the genetic data in conjunction with the disease and biomarker variables. The objectives are to enrich the current genetic analyses of neurological traits as well as to apply and evaluate genetic prediction scores to the ADNI sample.
Investigator's Name: Sonia Shah
Proposed Analysis: Analyse the genomics datasets in conjunction with the disease and biomarker variables. The objectives are to enrich the current genetic analyses of neurological traits as well as to apply and evaluate genetic prediction scores to the ADNI sample.
Investigator's Name: Peter Visscher
Proposed Analysis: Analyse the genetic data in conjunction with the disease and biomarker variables. The objectives are to enrich the current genetic analyses of neurological traits as well as to apply and evaluate genetic prediction scores to the ADNI sample.
Investigator's Name: Federica Cacciamani
Proposed Analysis: Analyse the relationship between neuropsychological scores and disease progression
Investigator's Name: Baptiste Criniere-Boizet
Proposed Analysis: Combine genetic and MRI prediction to enhance prediction accuracy of Alzheimer's risk, including conversion
Investigator's Name: Marta de Olivera Ferreira Nabais
Proposed Analysis: Methylation studies using ADNI and other samples
Investigator's Name: Allan McRae
Proposed Analysis: Methylation and brain studies or neurodegenerative diseases
Investigator's Name: Tian Lin
Proposed Analysis: Genomics and genetic studies of Alzheimer's and neurodegenerative disorders
Investigator's Name: Fleur Garton
Proposed Analysis: Genetic and genomic studies of neurodegenerative disorders.
Investigator's Name: Futao Zhang
Proposed Analysis: Genetic and genomics studies of neurodegenerative disorders