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Principal Investigator  
Principal Investigator's Name: Andrew Saykin
Institution: Indiana University School of Medicine
Department: Radiology/Center for Neuroimaging
Country: United States of America
Proposed Analysis: Our team will begin data preparation for extracting planned and novel MRI and PET endophenotypes for use in whole genome association analyses after the genetic data become available. In addition to planned analyses (e.g., hippocampal atrophy) we plan to employ pattern recognition tools to extract novel phenotypic information. Further details are available upon request and we welcome collaborative projects with other groups.
Additional Investigators  
Investigator's Name: Shannon Risacher
Proposed Analysis: Our team will begin data preparation for extracting planned and novel MRI and PET endophenotypes for use in whole genome association analyses after the genetic data become available. In addition to planned analyses (e.g., hippocampal atrophy) we plan to employ pattern recognition tools to extract novel phenotypic information. Further details are available upon request and we welcome collaborative projects with other groups.
Investigator's Name: Kwangsik Nho
Proposed Analysis: Genome wide analyses of neuroimaging data.
Investigator's Name: Jingwen Yan
Proposed Analysis: ADNI Genetics Core QC, analysis and collaboration as per the ADNI-3 specific aims for the core.
Investigator's Name: Tanner Jacobson
Proposed Analysis: PhD student working with the ADNI Genetics Core
Investigator's Name: Bobi Eastman
Proposed Analysis: Working on database curation for the ADNI Genetics Core.
Investigator's Name: Taeho Jo
Proposed Analysis: Working with the ADNI-3 Genetics Core on Deep Learning
Investigator's Name: Yen-Ning Huang
Proposed Analysis: ADNI data, among other cohorts, will be used by the Alzheimer’s Disease Sequencing Project Phenotype Harmonization Consortium (ADSP-PHC) investigators with the mission to facilitate phenotypic data harmonization for ADSP participants with genetic and genomic data. The ultimate goal of the ADSP-PHC is to generate harmonized data that will become a “legacy” dataset. This effort represents a multi-disciplinary approach leveraging interdisciplinary expertise in large-scale genetic and genomic studies, clinical neuroscience, neuroimaging, psychometrics, and bioinformatics. This proposal will procure, collate, curate, and harmonize endophenotype data from ADSP cohort studies including ADNI.
Investigator's Name: Quinn McBride
Proposed Analysis: ADNI Genetics Core Analyses including bile acids and other metabolomics data.