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Principal Investigator  
Principal Investigator's Name: Jinxin Chen
Institution: Chengdu University of TCM
Department: Clinial Medical College
Proposed Analysis: Alzheimer's disease is a degenerative disease of the nervous system with the main symptoms of memory and cognitive impairment. The etiology and pathogenesis of AD are complex. Bateman et al. showed that the clinical manifestations of AD are significantly later than that (later lagging from 10 to 25 years) in the pathological and physiological processes. Therefore, early diagnosis and intervention of AD are particularly important. AD patients not only show memory loss and cognitive impairment, but also often accompanied by sleep disorders, seriously affecting the quality of life of patients. More and more studies have also shown that sleep disorders AD risk factors, and increased AD progression . However, whether insomnia and AD have a common pathogenesis remains unclear. This study was designed to select patients who met the diagnostic criteria for AD in the American Neurology, Language Disorders, and the Association of the Stroke - NINCDS-ADRDA and the Diagnostic and Statistical Manual of Mental Disorders( DSM-V). the Diagnostic and Statistical Manual of Mental Disorders (DSM-V) diagnostic criteria for sleep disorders and AD-associated sleep disorders were studied . Head rs-fMRI was performed using a Siemens 3.0t magnetic resonance scanner.Data acquisition, using GRETNA , PANDA and other software to process the collected image data, using SPSS software for statistical analysis of the data, to explore the changes of brain structure and function of AD with sleep disorders, compare AD , sleep disorders and AD with sleep disorders The abnormality of the brain's network structure and function, and the relationship between AD and the pathogenesis of sleep disorders.
Additional Investigators