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Principal Investigator  
Principal Investigator's Name: David Cash
Institution: University College London
Department: Institute of Neurology
Proposed Analysis: Our group is currently one of the analysis centres for the Dominantly Inherited Alzheimer Network (DIAN). As the sites in DIAN are also members of ADNI and AIBL, we have hoped to use data from these cohorts for two objectives. The first objective is to enrich longitudinal analysis of structural MRI, using volumetric measurements, VBM, and the boundary shift integral, by bringing in control subjects enrolled at sites also involved in DIAN. The second is to compare the results of subjects with familial Alzheimer's disease to subjects with sporadic forms of AD and mild cognitive impairment. By using data at sites also involved with DIAN, we hope to limit the amount of instrument based variability.
Additional Investigators  
Investigator's Name: Thomas Veale
Proposed Analysis: Tom is a PhD student working on diffusion metrics along the cortical profile into the superficial white matter and wishes to look at the advanced diffusion imaging sequences available in ADNI3.