There are many active research projects accessing and applying shared ADNI data. Use the search above to find specific research focuses on the active ADNI investigations. This information is requested annually as a requirement for data access.
| Principal Investigator | |
| Principal Investigator's Name: | Diego Garrido |
| Institution: | Centre for Genomic Regulation |
| Department: | Bioinformatics and Genomics |
| Country: | |
| Proposed Analysis: | We aim to address the identification and analysis of genetic variants associated to multivariate neuroimaging phenotypes, accounting for additional relevant covariates. We have developed a non-parametric analogue to multivariate analysis of variance (MANOVA) that allows to assess significance for the association between a quantitative multivariate response and a set of explanatory variables. We are interested in applying it to MRI phenotypes, intrinsically multivariate, such as (but not restricted to) brain subregion's volumes or connectivity. Identifying genetic variants that alter human brain structures may reveal new biological mechanisms underlying cognition and neurodegenerative disorders, including Alzheimer's disease. |
| Additional Investigators |
