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Principal Investigator  
Principal Investigator's Name: Arunima Kapoor
Institution: Sunnybrook Health Sciences Centre
Department: Neurology
Proposed Analysis: Clinically important difference on neuropsychological tests is often defined using a distribution-based approach, with a change equivalent to one-half standard deviation or one standard error of measurement being considered clinically meaningful. However, whether such changes on neuropsychological assessments represent a change in functional and patient-centered outcomes remains unknown.The primary purpose of this is analysis to (1) evaluate whether neuropsychological assessment scores correlate with functional outcomes, (2) evaluate whether change in neuropsychological assessment scores correlates with changes in functional and patient-centered outcomes and establish a clinically meaningful change, (3) identify neuropsychological measures that are most sensitive to and predictive of functional change, and (4) explore whether clinically meaningful change correlates with neuroimaging measures.
Additional Investigators