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Principal Investigator  
Principal Investigator's Name: Alana Manson
Institution: University of Kansas Medical Center
Department: School of Nursing
Proposed Analysis: To our knowledge, no other studies have examined latent subtypes of risk profiles in MCI with AD etiology based on sex and clusters of diagnostic variables. If we can begin to understand how sociodemographic, clinical, cognitive, and biomarker variables combine to form subtypes of MCI with AD etiology, we may be able to better identify risk trajectories of decline. Therefore, the purpose of this study is to use latent class analysis in individuals with MCI due to AD to investigate if there are subtypes of risk profiles based on sex, sociodemographic, clinical, cognitive, and biomarker variables. Research questions include: 1) Among individuals with MCI with AD etiology, how do sociodemographic (age, education), clinical (CDR, functional assessment, subjective memory complaint, depressive symptoms), cognitive (global cognitive function, memory, executive function, language, visuospatial, attention/processing speed), and biomarker (hippocampal volume, APOE genotype) characteristics group by subtype? 2) To what extent do subtypes of MCI with AD etiology differ by sex?
Additional Investigators