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Principal Investigator  
Principal Investigator's Name: Rani Basna
Institution: University of Gothenburg, Institute of Medicine
Department: Internal medicine and clinical nutrition
Proposed Analysis: one of the projects we had in mind will be focussed on the regional onset and progression of neurodegenerative changes in AD. More than a decade ago there was this highly influential study by Whitwell et al. Brain 2007 (3D maps from multiple MRI illustrate changing atrophy patterns as subjects progress from mild cognitive impairment to Alzheimer's disease) which examined serial MRI measurements of MCI patients that later developed AD dementia and thus clearly showed how changes first appeared in the medial temporal lobe and then progressed to temporal, parietal, and finally frontal cortical areas. We propose to do a similar analysis for hypometabolic changes as measured by FDG-PET. Hypometabolism on FDG-PET is considered to be a more sensitive marker of neurodegeneration, but the exact patterns of regional onset and temporospatial progression are less well defined than for atrophy on MRI, mainly because research on FDG-PET is still mostly cross-sectional (as in our own previous study: Kljajevic, Grothe et al. NbA 2014). The ADNI database contains an exceptionally large collection of serial FDG-PET scans of longitudinally followed individuals which could be easily used to address this research question but has not yet been exploited to its fullest potential.
Additional Investigators