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Principal Investigator  
Principal Investigator's Name: huachang chen
Institution: Vanderbilt University Medical Center
Department: Biostatistics
Proposed Analysis: ADNI utilized both WGS and chip to genotype the same set of samples, which is very useful for us. In GWAS or many other research, imputation is widely used, however the accuracy evaluation of imputation result is hardly addressed. We'd like to use the genotype from the chip to get the imputated result, and use the coresponding WGS data to evaluate the accuracy of imputation.
Additional Investigators  
Investigator's Name: quanhu sheng
Proposed Analysis: we'd like to use the genotype data of HumanOmniExpress chip to do the impuation, and use the corresponding WGS data to evaluate the accuracy of current imputation pipeline.