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Principal Investigator  
Principal Investigator's Name: Vitaly Dobromyslin
Institution: University of Massachussetts, Lowell
Department: Biomedical Engineering
Country:
Proposed Analysis: Alzheimer disease (AD) diagnosis currently requires extensive neuropsychological assessment and brain imaging to confirm concordance of cognitive performance deficits with the characteristic neuroimaging biomarkers of AD. This approach is cost prohibitive and does not scale well to the aging population in resource-limited communities lacking access to the MRI machines required for neuroimaging. Gene expression and proteomics data collected from a blood sample provides a more readily accessible source of diagnostic information, which could aid in AD diagnosis. We propose to look for biomarkers in the gene expression and proteomics data co-varying with the cognitive performance levels and neuroimaging biomarkers, associated with progression to AD.
Additional Investigators