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Principal Investigator  
Principal Investigator's Name: Léonie Borne
Institution: University of Newcastle
Department: Systems Neuroscience Group
Proposed Analysis: The proposed analysis consists of identifying anatomical markers of dementia by analyzing structural MRIs from the ADNI database and comparing with other comparable large studies of ageing and dementia, including AIBL. In particular, sulcal measures (sulcal width and cortical thickness around the sulci) appear to be very promising. This type of measurements nevertheless requires a prior labeling of the sulci. For this purpose, this analysis will be based on an automatic cortical sulci recognition algorithm, recently proposed in the BrainVISA toolbox. This analysis will aim to study the covariation with measures of memory, language and executive function using unsupervised machine learning across controls, MCI and AD. In controls, the role of dementia risk (years of education, vascular risk, age, family and genetic factors) will be examined in modifying or mediating these relationships.
Additional Investigators