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Principal Investigator  
Principal Investigator's Name: Amin Haghani
Institution: University of California Los Angeles
Department: Human Genetics
Proposed Analysis: The analysis is about the association of brain DNA methylation changes and AD associated neuropathology. We are going to develop an epigenetic model of brain aging, and estimate the rate of age accelaration in brain samples. Next we will examine the association of rate of aging with AD associated pathology.
Additional Investigators  
Investigator's Name: Steve Horvath
Proposed Analysis: The project is about deveoping a brain aging DNA methylation model that can predict AD pathology. My lab is experienced in developing epigentic clocks as biomarkers of aging associated diseases. This project will optimize the model in brain samples with higher predictability for AD pathology and progress.