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Principal Investigator  
Principal Investigator's Name: Cara Woodworth
Institution: University of California, San Francisco
Department: Psychiatry
Proposed Analysis: I am a research coordinator working in Dr. Mackin's Late Life Depression (LLD) lab. We will be using ADNI data to assess clinical and neuroimaging characteristics of the ADNI-D sample relative to ADNI controls. We will be using a variety of data types from ADNI including structural and functional neuroimaging, cognition, independent function, fluid biomarkers, and genetics. Specific projects will a) clarify neurobiological substrates of cognitive dysfunction in LLD, b) clarify the impact of LLD on rate of cognitive decline over 2.5 years, and c) the assess the impact of reduced cerebral blood flow (hypoperfusion), cortical atrophy, and amyloid deposition on cognitive impairment and accelerated cognitive decline in LLD in the context of previously documented relationships between cognitive impairment and subcortical white matter abnormalities and genetic risk factors.
Additional Investigators